Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378.
Leukotriene A4 (LTA4) hydrolase [(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7, 9,11,14-tetraenoate hydrolase; EC 3.3.2.6] is a bifunctional zinc metalloenzyme that catalyzes the final step in the biosynthesis of the potent chemotactic agent leukotriene B4 (LTB4). LTA4 hydrolase/aminopeptidase is suicide...
| Principais autores: | , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
1996
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