Psychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates.
We have compared the ability of phencyclidine (PCP)-like or sigma ligands to induce psychomotor effects in primates. In squirrel monkeys, administration of MK-801 (0.001-0.1 mg/kg), PCP (0.03-0.3 mg/kg), (+)-SKF10047 (0.001-3.0 mg/kg) or (-)-SKF10047 (0.1-10 mg/kg) induced ataxia, head weaving and b...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1991
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