Psychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates.
We have compared the ability of phencyclidine (PCP)-like or sigma ligands to induce psychomotor effects in primates. In squirrel monkeys, administration of MK-801 (0.001-0.1 mg/kg), PCP (0.03-0.3 mg/kg), (+)-SKF10047 (0.001-3.0 mg/kg) or (-)-SKF10047 (0.1-10 mg/kg) induced ataxia, head weaving and b...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1991
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| _version_ | 1797079244513214464 |
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| author | Boyce, S Rupniak, N Steventon, M Cook, G Iversen, S |
| author_facet | Boyce, S Rupniak, N Steventon, M Cook, G Iversen, S |
| author_sort | Boyce, S |
| collection | OXFORD |
| description | We have compared the ability of phencyclidine (PCP)-like or sigma ligands to induce psychomotor effects in primates. In squirrel monkeys, administration of MK-801 (0.001-0.1 mg/kg), PCP (0.03-0.3 mg/kg), (+)-SKF10047 (0.001-3.0 mg/kg) or (-)-SKF10047 (0.1-10 mg/kg) induced ataxia, head weaving and bradykinesia. In contrast, treatment with the selective sigma ligand (+)-pentazocine using doses up to 20 mg/kg failed to induce any overt behaviours. The order of potency for induction of these behaviours was: MK-801 greater than PCP greater than (+)-SKF10047 greater than (-)-SKF10047 much greater than (+)-pentazocine. In rhesus monkeys treatment with MK-801 (0.01-0.04 mg/kg), PCP (0.05-0.2 mg/kg), (+)-SKF10047 (0.75-3.0 mg/kg) or (+)-pentazocine (1-10 mg/kg), disrupted performance of a spatial delayed response task. The potency to induce cognitive disruption was positively correlated with affinity for [3H]MK-801, but not [3H](+)-SKF10047, binding sites in vitro. These findings indicate that the psychomotor and cognitive effects of PCP-like and sigma ligands in primates are mediated through interactions at NMDA, not sigma, receptors. |
| first_indexed | 2024-03-07T00:43:01Z |
| format | Journal article |
| id | oxford-uuid:83b246fe-8a7d-4e4a-b7b1-bc684349a2a4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:43:01Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:83b246fe-8a7d-4e4a-b7b1-bc684349a2a42022-03-26T21:45:59ZPsychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:83b246fe-8a7d-4e4a-b7b1-bc684349a2a4EnglishSymplectic Elements at Oxford1991Boyce, SRupniak, NSteventon, MCook, GIversen, SWe have compared the ability of phencyclidine (PCP)-like or sigma ligands to induce psychomotor effects in primates. In squirrel monkeys, administration of MK-801 (0.001-0.1 mg/kg), PCP (0.03-0.3 mg/kg), (+)-SKF10047 (0.001-3.0 mg/kg) or (-)-SKF10047 (0.1-10 mg/kg) induced ataxia, head weaving and bradykinesia. In contrast, treatment with the selective sigma ligand (+)-pentazocine using doses up to 20 mg/kg failed to induce any overt behaviours. The order of potency for induction of these behaviours was: MK-801 greater than PCP greater than (+)-SKF10047 greater than (-)-SKF10047 much greater than (+)-pentazocine. In rhesus monkeys treatment with MK-801 (0.01-0.04 mg/kg), PCP (0.05-0.2 mg/kg), (+)-SKF10047 (0.75-3.0 mg/kg) or (+)-pentazocine (1-10 mg/kg), disrupted performance of a spatial delayed response task. The potency to induce cognitive disruption was positively correlated with affinity for [3H]MK-801, but not [3H](+)-SKF10047, binding sites in vitro. These findings indicate that the psychomotor and cognitive effects of PCP-like and sigma ligands in primates are mediated through interactions at NMDA, not sigma, receptors. |
| spellingShingle | Boyce, S Rupniak, N Steventon, M Cook, G Iversen, S Psychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates. |
| title | Psychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates. |
| title_full | Psychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates. |
| title_fullStr | Psychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates. |
| title_full_unstemmed | Psychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates. |
| title_short | Psychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates. |
| title_sort | psychomotor activity and cognitive disruption attributable to nmda but not sigma interactions in primates |
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