Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs
Osteoclasts are multinucleated, bone-resorbing cells. However, they also digest cartilage during skeletal maintenance, development and in degradative conditions including osteoarthritis, rheumatoid arthritis and primary bone sarcoma. This study explores the mechanisms behind the osteoclast–cartilage...
Main Authors: | Larrouture, Q, Cribbs, A, Rao, S, Philpott, M, Snelling, S, Knowles, H |
---|---|
Formato: | Journal article |
Idioma: | English |
Publicado: |
Springer Nature
2021
|
Títulos similares
-
Osteoclasts are multinucleated cells that degrade cartilage as well as bone
por: Larrouture, Q, et al.
Publicado: (2018) -
Osteoclasts are multinucleated cells that degrade cartilage as well as bone
por: Larrouture, QC
Publicado: (2019) -
Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes
por: Henrik Löfvall, et al.
Publicado: (2018-04-01) -
Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
por: Doo Ri Park, et al.
Publicado: (2020-08-01) -
Chondroclasts are mature osteoclasts which are capable of cartilage matrix resorption
por: Knowles, H, et al.
Publicado: (2012)