The three methyls: the function and therapeutic potential of histone H3K36 trimethylation

The three methyls: the function and therapeutic potential of histone H3K36 trimethylation

<p>DNA is wrapped around proteins called histones, whose modification regulates numerous cellular processes. Therefore it is not surprising that mutations in the genes that modify the histones are frequently associated with human cancer. For example, mutations in <em>SETD2</em>, en...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Pfister, SX
Awduron Eraill:	Humphrey, T
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2014
Pynciau:	Radiation Biology (medical sciences) Medical Sciences DNA damage signalling Oncology Tumours

Eitemau Tebyg

Selective targeting of homologous recombination deficiency
gan: Zimmer, J
Cyhoeddwyd: (2014)

Real-time studies of DNA repair kinetics following low-LET short-pulse electron radiation
gan: Mendes de Oliveira Martins, CD
Cyhoeddwyd: (2014)

Development of clinical biomarkers of DNA double strand breaks for cancer care
gan: Shah, K
Cyhoeddwyd: (2012)

The role of Wee1 in the hypoxia-induced DNA damage response and its potential as a therapeutic target
gan: O'Brien, EM
Cyhoeddwyd: (2012)

Novel regulation of SRC family kinase signalling by RASSF1 isoforms
gan: Scrace, SF
Cyhoeddwyd: (2013)

The role of ubiquitylation in regulating apurinic/apyrimidinic endonuclease 1
gan: Meisenberg, C
Cyhoeddwyd: (2012)

MiR-215 regulates differentiation in colorectal cancer stem cells
gan: Jones, M
Cyhoeddwyd: (2014)

Impact of TMPRSS2-ERG fusion gene on prostate cancer cell response to chemotherapy, radiotherapy and androgen deprivation therapy
gan: Ovtcharov, S
Cyhoeddwyd: (2015)

Base excision repair of radiation-induced DNA damage in mammalian cells
gan: Cooper, S, et al.
Cyhoeddwyd: (2013)

Development of bioreductive inhibitors of checkpoint kinase 1 to target hypoxic tumours
gan: Körner, C
Cyhoeddwyd: (2015)

The role of LATS1 in DNA damage signalling
gan: Latusek, R
Cyhoeddwyd: (2012)

Hypoxia-induced chromatin changes and ATM signalling
gan: Olcina del Molino, M
Cyhoeddwyd: (2014)

An analysis of the S. cerevisiae RMI1 gene
gan: Ashton, TM
Cyhoeddwyd: (2010)

The role of p53 in hypoxia-induced apoptosis
gan: Poole, R
Cyhoeddwyd: (2010)

The identification and validation of Auger electron-emitting radiopharmaceuticals targeting telomerase for cancer therapy
gan: Jackson, M
Cyhoeddwyd: (2013)

Targeting EGFR signalling pathway in triple negative breast cancer
gan: Albukhari, A
Cyhoeddwyd: (2014)

Targeting EGFR signalling pathway in triple negative breast cancer
gan: Albukhari, A
Cyhoeddwyd: (2014)

Tumour-stroma interaction in pancreatic cancer
gan: Lunardi, S
Cyhoeddwyd: (2013)

Characterising the role of circulating immune cells in brain metastasis
gan: Balathasan, L
Cyhoeddwyd: (2012)

Therapeutic targeting of histone H3 lysine 36 trimethylation-deficient cancers
gan: Lopez, K
Cyhoeddwyd: (2019)

Novel signalling pathways regulating epithelial-mesenchymal transition in bone metastatic prostate cancer
gan: Rao, SR
Cyhoeddwyd: (2014)

Combining regulatory angiogenic gene therapy and virotherapy for the treatment of breast cancer
gan: Bazan Peregrino, M
Cyhoeddwyd: (2007)

Modulating the immune system by amino acid depletion - IDO and beyond
gan: Vallius, L
Cyhoeddwyd: (2011)

The role of nitric oxide as a hypoxic cell radiosensitizer
gan: Folkes, L
Cyhoeddwyd: (2013)

The role of ATF4 in hypoxia-induced cell death in cancer
gan: Pike, L, et al.
Cyhoeddwyd: (2011)

Managing melanoma in the era of personalised therapy: more than one disease
gan: Rughani, M, et al.
Cyhoeddwyd: (2012)

The role of host microenvironment in the pathogenesis of multiple myeloma
gan: Lwin, STS
Cyhoeddwyd: (2014)

Investigating a role of ASPP2 in the cellular response to infection
gan: Lim, Y, et al.
Cyhoeddwyd: (2014)

Investigating the role of DNA double strand break repair in determining sensitivity to radiotherapy fraction size
gan: Somaiah, N
Cyhoeddwyd: (2014)

Targeting PDK and PARP to improve radiation response in preclinical models of non-small cell lung cancer
gan: Verbiest, T
Cyhoeddwyd: (2013)

Development of models and methods to assess the efficacy of anti-cancer drugs targeted to the mitochondria
gan: Potter, M
Cyhoeddwyd: (2014)

Improving intraperitoneal adenovirus virotherapy for ovarian cancer
gan: Thoma, CMM
Cyhoeddwyd: (2011)

The role of DLL4-NOTCH signalling in endothelial cell metabolism
gan: Harjes, U
Cyhoeddwyd: (2014)

Investigation into the regulatory mechanism of BRCA2 stability
gan: Gruber, C
Cyhoeddwyd: (2013)

Mitochondrial modulators of hypoxia-related pathways in tumours
gan: Snell, CE
Cyhoeddwyd: (2013)

DNA damage responses to loss of telomere integrity
gan: Carlos, AR
Cyhoeddwyd: (2013)

HR23B, a biomarker for HDAC inhibitors
gan: Khan, OA
Cyhoeddwyd: (2013)

Arginine methylation in the E2F1 pathway
gan: Zheng, S
Cyhoeddwyd: (2013)

The role of HER4 in relation to trastuzumab resistance and prognosis in HER2 positive breast cancer
gan: Mohd Nafi, SN
Cyhoeddwyd: (2014)

Regulation of stemness and differentiation in colorectal cancer
gan: Gandhi, S
Cyhoeddwyd: (2010)