Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance.
It is now possible to induce donor-specific transplantation tolerance in adult rodents using non-depleting monoclonal antibodies against T cell co-receptor and co-stimulation molecules or by immunisation with tolerogenic antigen-presenting cells. It is a common finding of all these models of periphe...
| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
2003
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| _version_ | 1826282404681089024 |
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| author | Cobbold, S Graca, L Lin, C Adams, E Waldmann, H |
| author_facet | Cobbold, S Graca, L Lin, C Adams, E Waldmann, H |
| author_sort | Cobbold, S |
| collection | OXFORD |
| description | It is now possible to induce donor-specific transplantation tolerance in adult rodents using non-depleting monoclonal antibodies against T cell co-receptor and co-stimulation molecules or by immunisation with tolerogenic antigen-presenting cells. It is a common finding of all these models of peripheral tolerance, as well as of various mouse models of autoimmune disease, that regulatory CD4(+) T cells are the principal mediators. There are currently no specific markers for regulatory T cells, but in some autoimmune models their activity has been associated with the expression of activation markers such as CD25 and CTLA4, or anti-inflammatory cytokines such as IL-10 and TGF-beta. CD4(+)CD25(+) T cells from both naïve and tolerised donors are able to transfer tolerance to grafts in lymphopenic recipients, and this may be directly applicable to bone-marrow transplantation. The challenge is now to understand the biological principles that allow such immune re-programming so that they can be safely applied to clinical organ grafting. |
| first_indexed | 2024-03-07T00:43:21Z |
| format | Journal article |
| id | oxford-uuid:83d0877b-f075-444b-856d-3783fde3959b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:43:21Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:83d0877b-f075-444b-856d-3783fde3959b2022-03-26T21:46:44ZRegulatory T cells in the induction and maintenance of peripheral transplantation tolerance.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:83d0877b-f075-444b-856d-3783fde3959bEnglishSymplectic Elements at Oxford2003Cobbold, SGraca, LLin, CAdams, EWaldmann, HIt is now possible to induce donor-specific transplantation tolerance in adult rodents using non-depleting monoclonal antibodies against T cell co-receptor and co-stimulation molecules or by immunisation with tolerogenic antigen-presenting cells. It is a common finding of all these models of peripheral tolerance, as well as of various mouse models of autoimmune disease, that regulatory CD4(+) T cells are the principal mediators. There are currently no specific markers for regulatory T cells, but in some autoimmune models their activity has been associated with the expression of activation markers such as CD25 and CTLA4, or anti-inflammatory cytokines such as IL-10 and TGF-beta. CD4(+)CD25(+) T cells from both naïve and tolerised donors are able to transfer tolerance to grafts in lymphopenic recipients, and this may be directly applicable to bone-marrow transplantation. The challenge is now to understand the biological principles that allow such immune re-programming so that they can be safely applied to clinical organ grafting. |
| spellingShingle | Cobbold, S Graca, L Lin, C Adams, E Waldmann, H Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance. |
| title | Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance. |
| title_full | Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance. |
| title_fullStr | Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance. |
| title_full_unstemmed | Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance. |
| title_short | Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance. |
| title_sort | regulatory t cells in the induction and maintenance of peripheral transplantation tolerance |
| work_keys_str_mv | AT cobbolds regulatorytcellsintheinductionandmaintenanceofperipheraltransplantationtolerance AT gracal regulatorytcellsintheinductionandmaintenanceofperipheraltransplantationtolerance AT linc regulatorytcellsintheinductionandmaintenanceofperipheraltransplantationtolerance AT adamse regulatorytcellsintheinductionandmaintenanceofperipheraltransplantationtolerance AT waldmannh regulatorytcellsintheinductionandmaintenanceofperipheraltransplantationtolerance |