Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin.

Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin.

Low extracellular pH (pH(e)), that is characteristic of many tumours, tends to reduce the uptake of weakly basic drugs, such as doxorubicin, thereby conferring a degree of physiological resistance to chemotherapy. It has been assumed, from pH-partition theory, that the effect of intracellular pH (pH...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Swietach, P, Hulikova, A, Patiar, S, Vaughan-Jones, R, Harris, A
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	Public Library of Science 2012

Gelijkaardige items

Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia.
door: Hulikova, A, et al.
Gepubliceerd in: (2013)

The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths.
door: Swietach, P, et al.
Gepubliceerd in: (2009)

Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths.
door: Hulikova, A, et al.
Gepubliceerd in: (2011)

Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes.
door: Swietach, P, et al.
Gepubliceerd in: (2010)

Intracellular pH regulation in heart.
door: Vaughan-Jones, R, et al.
Gepubliceerd in: (2009)

Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure
door: Hulikova, A, et al.
Gepubliceerd in: (2014)

Spatial regulation of intracellular pH in the ventricular myocyte.
door: Swietach, P, et al.
Gepubliceerd in: (2005)

Spatial aspects of intracellular pH regulation in heart muscle.
door: Vaughan-Jones, R, et al.
Gepubliceerd in: (2006)

The chemistry, physiology and pathology of pH in cancer.
door: Swietach, P, et al.
Gepubliceerd in: (2014)

The relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes
door: Swietach, P, et al.
Gepubliceerd in: (2005)

Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes.
door: Swietach, P, et al.
Gepubliceerd in: (2005)

Acid-extrusion from tissue: the interplay between membrane transporters and pH buffers.
door: Hulikova, A, et al.
Gepubliceerd in: (2012)

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
door: Swietach, P, et al.
Gepubliceerd in: (2010)

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation.
door: Swietach, P, et al.
Gepubliceerd in: (2010)

Experimental generation and computational modeling of intracellular pH gradients in cardiac myocytes.
door: Swietach, P, et al.
Gepubliceerd in: (2005)

H⁺-activated Na⁺ influx in the ventricular myocyte couples Ca²⁺-signalling to intracellular pH.
door: Garciarena, C, et al.
Gepubliceerd in: (2013)

Spatial Control of pH(i) in the Heart, and Its Influence on the Local Control of Intracellular Ca2+ Signaling
door: Vaughan-Jones, R, et al.
Gepubliceerd in: (2009)

Na⁺ ions as spatial intracellular messengers for co-ordinating Ca²⁺ signals during pH heterogeneity in cardiomyocytes.
door: Swietach, P, et al.
Gepubliceerd in: (2015)

Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.
door: Swietach, P, et al.
Gepubliceerd in: (2008)

Comparative efficacy of novel platinum(IV) compounds with established chemotherapeutic drugs in solid tumour models.
door: Hall, MD, et al.
Gepubliceerd in: (2004)

H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH
door: Garciarena, C, et al.
Gepubliceerd in: (2013)

Local release of caged protons by UV flash photolysis as a means of producing intracellular pH non-uniformity
door: Swietach, P, et al.
Gepubliceerd in: (2005)

Temperature dependence of Na+-H+ exchange, Na+-HCO3- co-transport, intracellular buffering and intracellular pH in guinea-pig ventricular myocytes.
door: Ch'en, F, et al.
Gepubliceerd in: (2003)

H+ ion activation and inactivation of the ventricular gap junction: a basis for spatial regulation of intracellular pH.
door: Swietach, P, et al.
Gepubliceerd in: (2007)

Development of TCM herb and chemotherapeutic drug interaction database
door: Yen, Sheng Xiang
Gepubliceerd in: (2014)

Synergetic effect of cysteine rich protein and chemotherapeutic drugs.
door: Wong, Liling.
Gepubliceerd in: (2013)

Emergence of spatio-temporal variations in chemotherapeutic drug efficacy : in-vitro and in-silico 3D tumour spheroid studies
door: Sheraton, Muniraj Vivek, et al.
Gepubliceerd in: (2021)

pH-sensitive core-shell nanoparticles for intracellular drug delivery
door: Hu, Yuhua, Ph. D. Massachusetts Institute of Technology
Gepubliceerd in: (2008)

Antibacterial chemotherapeutic agents /
door: 396429 Dax, Scott L.
Gepubliceerd in: (1997)

A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug
door: Zhao, Yang, et al.
Gepubliceerd in: (2015)

Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle.
door: Bountra, C, et al.
Gepubliceerd in: (1989)

Regulation of tumor pH and the role of carbonic anhydrase 9.
door: Swietach, P, et al.
Gepubliceerd in: (2007)

Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes.
door: Garciarena, C, et al.
Gepubliceerd in: (2013)

Innovating cancer drug discovery with refined phenotypic screens
door: Wang, Z, et al.
Gepubliceerd in: (2024)

Intracellular pH regulation in rabbit isolated sino-atrial node cells
door: Buckler, K, et al.
Gepubliceerd in: (1990)

Application of a new pH-sensitive fluoroprobe (carboxy-SNARF-1) for intracellular pH measurement in small, isolated cells.
door: Buckler, K, et al.
Gepubliceerd in: (1990)

The modulation of intracellular pH in carotid body glomus cells by extracellular pH and pCO2.
door: Buckler, K, et al.
Gepubliceerd in: (1993)

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine
door: Geller, Leore T., et al.
Gepubliceerd in: (2020)

A model of quiescent tumour microregions for evaluating multicellular resistance to chemotherapeutic drugs.
door: Mellor, H, et al.
Gepubliceerd in: (2005)

Modelling intracellular H(+) ion diffusion.
door: Swietach, P, et al.
Gepubliceerd in: (2003)