Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.
Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that en...
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| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
Oxford University Press
2013
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| _version_ | 1826282529911472128 |
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| author | Kote-Jarai, Z Saunders, E Leongamornlert, D Tymrakiewicz, M Dadaev, T Jugurnauth-Little, S Ross-Adams, H Al Olama, A Benlloch, S Halim, S Russell, R Russel, R Dunning, A Luccarini, C Dennis, J Neal, D Hamdy, F Donovan, J Muir, K Giles, G Severi, G Wiklund, F Gronberg, H Haiman, C Schumacher, F Henderson, B Le Marchand, L Lindstrom, S Kraft, P Hunter, D Gapstur, S Chanock, S Berndt, S Albanes, D Andriole, G Schleutker, J Weischer, M Canzian, F Riboli, E Key, T Travis, R Campa, D Ingles, SA John, E Hayes, R Pharoah, P Khaw, K Stanford, J Ostrander, E Signorello, L Thibodeau, SN Schaid, D Maier, C Vogel, W Kibel, A Cybulski, C Lubinski, J Cannon-Albright, L Brenner, H Park, J Kaneva, R Batra, J Spurdle, A Clements, J Teixeira, MR Govindasami, K Guy, M Wilkinson, R Sawyer, E Morgan, A Dicks, E Baynes, C Conroy, D Bojesen, SE Kaaks, R Vincent, D Bacot, F Tessier, D Easton, D Eeles, R |
| author_facet | Kote-Jarai, Z Saunders, E Leongamornlert, D Tymrakiewicz, M Dadaev, T Jugurnauth-Little, S Ross-Adams, H Al Olama, A Benlloch, S Halim, S Russell, R Russel, R Dunning, A Luccarini, C Dennis, J Neal, D Hamdy, F Donovan, J Muir, K Giles, G Severi, G Wiklund, F Gronberg, H Haiman, C Schumacher, F Henderson, B Le Marchand, L Lindstrom, S Kraft, P Hunter, D Gapstur, S Chanock, S Berndt, S Albanes, D Andriole, G Schleutker, J Weischer, M Canzian, F Riboli, E Key, T Travis, R Campa, D Ingles, SA John, E Hayes, R Pharoah, P Khaw, K Stanford, J Ostrander, E Signorello, L Thibodeau, SN Schaid, D Maier, C Vogel, W Kibel, A Cybulski, C Lubinski, J Cannon-Albright, L Brenner, H Park, J Kaneva, R Batra, J Spurdle, A Clements, J Teixeira, MR Govindasami, K Guy, M Wilkinson, R Sawyer, E Morgan, A Dicks, E Baynes, C Conroy, D Bojesen, SE Kaaks, R Vincent, D Bacot, F Tessier, D Easton, D Eeles, R |
| author_sort | Kote-Jarai, Z |
| collection | OXFORD |
| description | Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that encodes TERT. To comprehensively evaluate the association between genetic variation across this region and PrCa, we performed a fine-mapping analysis by genotyping 134 SNPs using a custom Illumina iSelect array or Sequenom MassArray iPlex, followed by imputation of 1094 SNPs in 22 301 PrCa cases and 22 320 controls in The PRACTICAL consortium. Multiple stepwise logistic regression analysis identified four signals in the promoter or intronic regions of TERT that independently associated with PrCa risk. Gene expression analysis of normal prostate tissue showed evidence that SNPs within one of these regions also associated with TERT expression, providing a potential mechanism for predisposition to disease. |
| first_indexed | 2024-03-07T00:45:14Z |
| format | Journal article |
| id | oxford-uuid:846da098-ffb8-4c5b-8680-7dfa8b338707 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:45:14Z |
| publishDate | 2013 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:846da098-ffb8-4c5b-8680-7dfa8b3387072022-03-26T21:51:07ZFine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:846da098-ffb8-4c5b-8680-7dfa8b338707EnglishSymplectic Elements at OxfordOxford University Press2013Kote-Jarai, ZSaunders, ELeongamornlert, DTymrakiewicz, MDadaev, TJugurnauth-Little, SRoss-Adams, HAl Olama, ABenlloch, SHalim, SRussell, RRussel, RDunning, ALuccarini, CDennis, JNeal, DHamdy, FDonovan, JMuir, KGiles, GSeveri, GWiklund, FGronberg, HHaiman, CSchumacher, FHenderson, BLe Marchand, LLindstrom, SKraft, PHunter, DGapstur, SChanock, SBerndt, SAlbanes, DAndriole, GSchleutker, JWeischer, MCanzian, FRiboli, EKey, TTravis, RCampa, DIngles, SAJohn, EHayes, RPharoah, PKhaw, KStanford, JOstrander, ESignorello, LThibodeau, SNSchaid, DMaier, CVogel, WKibel, ACybulski, CLubinski, JCannon-Albright, LBrenner, HPark, JKaneva, RBatra, JSpurdle, AClements, JTeixeira, MRGovindasami, KGuy, MWilkinson, RSawyer, EMorgan, ADicks, EBaynes, CConroy, DBojesen, SEKaaks, RVincent, DBacot, FTessier, DEaston, DEeles, RAssociations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that encodes TERT. To comprehensively evaluate the association between genetic variation across this region and PrCa, we performed a fine-mapping analysis by genotyping 134 SNPs using a custom Illumina iSelect array or Sequenom MassArray iPlex, followed by imputation of 1094 SNPs in 22 301 PrCa cases and 22 320 controls in The PRACTICAL consortium. Multiple stepwise logistic regression analysis identified four signals in the promoter or intronic regions of TERT that independently associated with PrCa risk. Gene expression analysis of normal prostate tissue showed evidence that SNPs within one of these regions also associated with TERT expression, providing a potential mechanism for predisposition to disease. |
| spellingShingle | Kote-Jarai, Z Saunders, E Leongamornlert, D Tymrakiewicz, M Dadaev, T Jugurnauth-Little, S Ross-Adams, H Al Olama, A Benlloch, S Halim, S Russell, R Russel, R Dunning, A Luccarini, C Dennis, J Neal, D Hamdy, F Donovan, J Muir, K Giles, G Severi, G Wiklund, F Gronberg, H Haiman, C Schumacher, F Henderson, B Le Marchand, L Lindstrom, S Kraft, P Hunter, D Gapstur, S Chanock, S Berndt, S Albanes, D Andriole, G Schleutker, J Weischer, M Canzian, F Riboli, E Key, T Travis, R Campa, D Ingles, SA John, E Hayes, R Pharoah, P Khaw, K Stanford, J Ostrander, E Signorello, L Thibodeau, SN Schaid, D Maier, C Vogel, W Kibel, A Cybulski, C Lubinski, J Cannon-Albright, L Brenner, H Park, J Kaneva, R Batra, J Spurdle, A Clements, J Teixeira, MR Govindasami, K Guy, M Wilkinson, R Sawyer, E Morgan, A Dicks, E Baynes, C Conroy, D Bojesen, SE Kaaks, R Vincent, D Bacot, F Tessier, D Easton, D Eeles, R Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. |
| title | Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. |
| title_full | Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. |
| title_fullStr | Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. |
| title_full_unstemmed | Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. |
| title_short | Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. |
| title_sort | fine mapping identifies multiple prostate cancer risk loci at 5p15 one of which associates with tert expression |
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