Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors

The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templat...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Holt-Martyn, JP, Chowdhury, R, Tumber, A, Yeh, T-L, Abboud, MI, Lippl, K, Lohans, CT, Langley, GW, Figg Jr, W, McDonough, MA, Pugh, CW, Ratcliffe, PJ, Schofield, CJ
التنسيق: Journal article
اللغة:English
منشور في: Wiley 2019