Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors

The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templat...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Holt-Martyn, JP, Chowdhury, R, Tumber, A, Yeh, T-L, Abboud, MI, Lippl, K, Lohans, CT, Langley, GW, Figg Jr, W, McDonough, MA, Pugh, CW, Ratcliffe, PJ, Schofield, CJ
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: Wiley 2019