Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors

The 2‐oxoglutarate‐dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templat...

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Bibliographic Details
Main Authors:	Holt-Martyn, JP, Chowdhury, R, Tumber, A, Yeh, T-L, Abboud, MI, Lippl, K, Lohans, CT, Langley, GW, Figg Jr, W, McDonough, MA, Pugh, CW, Ratcliffe, PJ, Schofield, CJ
Format:	Journal article
Language:	English
Published:	Wiley 2019

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