Structure-based design of an in vivo active selective BRD9 inhibitor

Components of the chromatin remodelling switch/sucrose nonfermentable (SWI/SNF) complex are recurrently mutated in tumors, suggesting that altering the activity of the complex plays a role in oncogenesis. However, the role that the individual subunits play in this process is not clear. We set out to...

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Main Authors:	Martin, LJ, Koegl, M, Bader, G, Cockcroft, Z, Fedorov, O, Fiegen, D, Gerstberger, T, Hofmann, M, Hohmann, AF, Kessler, D, Knapp, S, Knesl, P, Kornigg, S, Müller, S, Nar, H, Rogers, C, Rumpel, K, Schaaf, O, Steurer, S, Tallant, C, Vakoc, CR, Zeeb, M, Zoephel, A, Pearson, M, Boehmelt, G, McConnell, D
Format:	Journal article
Language:	English
Published:	American Chemical Society 2016

Structure-based design of an in vivo active selective BRD9 inhibitor

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