Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless Asymmetric Dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4
Our synthesis of the CDE ring fragment of pectenotoxin-4 utilised two key steps to make the complex bicyclic ketal unit: (i) a rhodium-catalysed vinyl group 1,4-addition as the major C–C bond forming step; (ii) a stereoselective Sharpless Asymmetric Dihydroxylation (SAD) of the resulting 1,1-disubst...
| Main Authors: | , , , |
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| 格式: | Journal article |
| 出版: |
Royal Society of Chemistry
2019
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