Progress in the synthesis of the lituarines: stereocontrol in sequential C-C bond formation on a spirobutenolide template.
[structure: see text] We describe elaboration of a tricyclic spirobutenolide corresponding to the C(7-18) tricyclic substructure common to lituarines A-C. Conjugate addition, to install the C(16) methyl, is followed by construction of the crucial C(18-19) bond by silyl enol ether addition to the der...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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