Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia

Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia

Ribosome dysfunction underlies the pathogenesis of many cancers and heritable ribosomopathies. Here, we investigate how mutations in either ribosomal protein large (RPL) or ribosomal protein small (RPS) subunit genes selectively affect erythroid progenitor development and clinical phenotypes in Diam...

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Bibliographic Details
Main Authors: Iskander, D, Wang, G, Heuston, EF, Christodoulidou, C, Psaila, B, Ponnusamy, K, Ren, H, Mokhtari, Z, Robinson, M, Chaidos, A, Trivedi, P, Trasanidis, N, Katsarou, A, Szydlo, R, Palii, CG, Zaidi, MH, Al-Oqaily, Q, Caputo, VS, Roy, A, Harrington, Y, Karnik, L, Naresh, K, Mead, AJ, Thongjuea, S, Brand, M, de la Fuente, J, Bodine, DM, Roberts, I, Karadimitris, A
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2021

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