Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia

Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia

Ribosome dysfunction underlies the pathogenesis of many cancers and heritable ribosomopathies. Here, we investigate how mutations in either ribosomal protein large (RPL) or ribosomal protein small (RPS) subunit genes selectively affect erythroid progenitor development and clinical phenotypes in Diam...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Iskander, D, Wang, G, Heuston, EF, Christodoulidou, C, Psaila, B, Ponnusamy, K, Ren, H, Mokhtari, Z, Robinson, M, Chaidos, A, Trivedi, P, Trasanidis, N, Katsarou, A, Szydlo, R, Palii, CG, Zaidi, MH, Al-Oqaily, Q, Caputo, VS, Roy, A, Harrington, Y, Karnik, L, Naresh, K, Mead, AJ, Thongjuea, S, Brand, M, de la Fuente, J, Bodine, DM, Roberts, I, Karadimitris, A
Aineistotyyppi: Journal article
Kieli:English
Julkaistu: American Association for the Advancement of Science 2021

Samankaltaisia teoksia