Adaptations to Maintain Energy Homeostasis Compensate for Creatine-Deficiency in GAMT Knockout Mice Following Myocardial Infarction, but May Contribute to Early Mitochondrial Pathology During Aging

Geahča maid

• Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
  Dahkki: Lygate, C, et al.
  Almmustuhtton: (2012)
• Regulation of Myocardial Creatine Uptake by Intra- and Extracellular Creatine Levels
  Dahkki: Makinen, K, et al.
  Almmustuhtton: (2008)
• Hearts from gamt ko mice lack phospho-creatine, show reduced inotropic reserve and are more prone to ischemia
  Dahkki: ten Hove, M, et al.
  Almmustuhtton: (2005)
• COMPENSATION FOR IMPAIRED MYOCARDIAL PHOSPHOTRANSFER IN GUANIDINOACETATE-N-METHYLTRANSFERASE KNOCKOUT MICE
  Dahkki: Aksentijevic, D, et al.
  Almmustuhtton: (2010)
• Unchanged Mitochondrial Organization and Compartmentation in Creatine Deficient GAMT-/- Mouse Heart
  Dahkki: Branovets, J, et al.
  Almmustuhtton: (2013)