Adaptations to Maintain Energy Homeostasis Compensate for Creatine-Deficiency in GAMT Knockout Mice Following Myocardial Infarction, but May Contribute to Early Mitochondrial Pathology During Aging

Eitemau Tebyg

• Hearts from gamt ko mice lack phospho-creatine, show reduced inotropic reserve and are more prone to ischemia
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• Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
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• COMPENSATION FOR IMPAIRED MYOCARDIAL PHOSPHOTRANSFER IN GUANIDINOACETATE-N-METHYLTRANSFERASE KNOCKOUT MICE
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• Regulation of Myocardial Creatine Uptake by Intra- and Extracellular Creatine Levels
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• Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics
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