Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.

An important step toward improving the annotation of the human genome is to identify cis-acting regulatory elements from primary DNA sequence. One approach is to compare sequences from multiple, divergent species. This approach distinguishes multispecies conserved sequences (MCS) in noncoding region...

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Bibliographic Details
Main Authors: Hughes, J, Cheng, J, Ventress, N, Prabhakar, S, Clark, K, Anguita, E, De Gobbi, M, de Jong, P, Rubin, E, Higgs, D
Format: Journal article
Language:English
Published: 2005