Low-voltage-activated A-current controls the firing dynamics of mouse hypothalamic orexin neurons.

The activity of hypothalamic neurons that release the neuropeptides orexin-A and orexin-B is essential for normal wakefulness. Orexin neurons fire spontaneously and are hyperpolarized and inhibited by physiological neuromodulators, but the intrinsic determinants of their electrical activity are poor...

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Bibliographic Details
Main Authors: Burdakov, D, Alexopoulos, H, Vincent, A, Ashcroft, F
Format: Journal article
Language:English
Published: 2004