Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure.

BACKGROUND: Elevated plasma norepinephrine levels are associated with increased mortality in patients and in animal models with chronic heart failure. To test which alpha2-adrenoceptor subtypes operate as presynaptic inhibitory receptors to control norepinephrine release in heart failure, we invest...

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Bibliographic Details
Main Authors: Brede, M, Wiesmann, F, Jahns, R, Hadamek, K, Arnolt, C, Neubauer, S, Lohse, M, Hein, L
Format: Journal article
Language:English
Published: 2002