Structure of the Fanconi anaemia monoubiquitin ligase complex

The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress1,2. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC) proteins impairs development, prevents blood pro...

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Bibliographic Details
Main Authors: Shakeel, S, Rajendra, E, Alcón, P, O'Reilly, F, Chorev, D, Maslen, S, Degliesposti, G, Russo, C, He, S, Hill, C, Skehel, J, Scheres, S, Patel, K, Rappsilber, J, Robinson, C, Passmore, L
Format: Journal article
Language:English
Published: Nature Research 2019