Molecular basis for redox control by the human cystine/glutamate antiporter system xc−

Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability of cysteine. However, circulating cysteine exists in the blood as the oxidised di-peptide cystine, requiring sp...

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Bibliographic Details
Main Authors: Parker, J, Deme, J, Kolokouris, D, Kuteyi, G, Biggin, P, Lea, S, Newstead, S
Format: Journal article
Language:English
Published: Springer Nature 2021