BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma

BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma

Whether cell types exposed to a high level of environmental insults possess cell type-specific prosurvival mechanisms or enhanced DNA damage repair capacity is not well understood. BRN2 is a tissue-restricted POU domain transcription factor implicated in neural development and several cancers. In me...

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Bibliographic Details
Main Authors: Herbert, K, Binet, R, Lambert, J-P, Louphrasitthiphol, P, Kalkavan, H, Sanz, LS, Robles-Espinoza, CD, Sarkar, S, Suer, E, Andrews, S, Chauhan, J, Roberts, ND, Middleton, M, Gingras, A-C, Masson, J-Y, Larue, L, Falletta, P, Goding, C
Format: Journal article
Published: Cold Spring Harbor Laboratory Press 2019

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