Synthesis of 4-aminomethyl-tetrahydrofuran-2-carboxylates with 2,4-cis and 2,4-trans relationships

Templated tetrahydrofuran-based γ-azido esters were prepared with the C-2 and C-4 functionalities in cis and trans relative configurations. This was achieved by ring contraction of the suitably protected 2-O-triflates of pentono-1,5-lactones (d-ribose and l-arabinose) with subsequent introduction of...

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Bibliographic Details
Main Authors: Edwards, A, Sanjayan, G, Hachisu, S, Soengas, R, Stewart, A, Tranter, G, Fleet, G
Format: Journal article
Language:English
Published: 2006