Delivery of oligonucleotide‐based therapeutics: challenges and opportunities
Nucleic acid‐based therapeutics that regulate gene expression have been developed towards clinical use at a steady pace for several decades, but in recent years the field has been accelerating. To date, there are 11 marketed products based on antisense oligonucleotides, aptamers and small interferin...
Main Authors: | Hammond, SM, Aartsma‐Rus, A, Alves, S, Borgos, SE, Buijsen, RAM, Collin, RWJ, Covello, G, Denti, MA, Desviat, LR, Echevarría, L, Foged, C, Gaina, G, Garanto, A, Goyenvalle, AT, Guzowska, M, Holodnuka, I, Jones, DR, Krause, S, Lehto, T, Montolio, M, Van Roon‐Mom, W, Arechavala‐Gomeza, V |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Springer
2021
|
Similar Items
-
Delivery is key: lessons learnt from developing splice-switching antisense therapies
by: Godfrey, C, et al.
Published: (2017) -
Challenges to oligonucleotides-based therapeutics for Duchenne muscular dystrophy.
by: Goyenvalle, A, et al.
Published: (2011) -
Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides.
by: Hassane, F, et al.
Published: (2011) -
Cardiac complications of propionic and other inherited organic acidemias
by: Park, KC, et al.
Published: (2020) -
Oligonucleotides for the identification of staphylococcus aureus.
by: Shamsudin, Mariana Nor, et al.
Published: (2006)