Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, com...

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Үндсэн зохиолчид:	Mahajan, A, Taliun, D, Thurner, M, Robertson, N, Torres, J, Rayner, N, Payne, A, Bennett, A, Nylander, V, Lindgren, C, Marchini, J, Gloyn, A, Morris, A, McCarthy, M, al., E
Формат:	Journal article
Хэвлэсэн:	Springer Nature 2018

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