GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels

Glucagon is the body's main hyperglycemic hormone, and its secretion is dysregulated in type 2 diabetes mellitus (T2DM). The incretin hormone glucagon‐like peptide‐1 (GLP‐1) is released from the gut and is used in T2DM therapy. Uniquely, it both stimulates insulin and inhibits glucagon secretio...

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Príomhchruthaitheoirí: Ramracheya, R, Chapman, C, Chibalina, M, Dou, H, Miranda, C, González, A, Moritoh, Y, Shigeto, M, Zhang, Q, Braun, M, Clarke, A, Johnson, P, Rorsman, P, Briant, L
Formáid: Journal article
Foilsithe / Cruthaithe: Wiley 2018