Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.

In two previously described donors, the extracellular domain of LAIR1, a collagen-binding inhibitory receptor encoded on chromosome 19 (ref. 1), was inserted between the V and DJ segments of an antibody. This insertion generated, through somatic mutations, broadly reactive antibodies against RIFINs,...

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Bibliographic Details
Main Authors:	Pieper, K, Tan, J, Piccoli, L, Foglierini, M, Barbieri, S, Chen, Y, Silacci-Fregni, C, Wolf, T, Jarrossay, D, Anderle, M, Abdi, A, Ndungu, F, Doumbo, O, Traore, B, Tran, T, Jongo, S, Zenklusen, I, Crompton, P, Daubenberger, C, Bull, P, Sallusto, F, Lanzavecchia, A
Format:	Journal article
Language:	English
Published:	Nature Research 2017

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.

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