Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
In two previously described donors, the extracellular domain of LAIR1, a collagen-binding inhibitory receptor encoded on chromosome 19 (ref. 1), was inserted between the V and DJ segments of an antibody. This insertion generated, through somatic mutations, broadly reactive antibodies against RIFINs,...
Main Authors: | Pieper, K, Tan, J, Piccoli, L, Foglierini, M, Barbieri, S, Chen, Y, Silacci-Fregni, C, Wolf, T, Jarrossay, D, Anderle, M, Abdi, A, Ndungu, F, Doumbo, O, Traore, B, Tran, T, Jongo, S, Zenklusen, I, Crompton, P, Daubenberger, C, Bull, P, Sallusto, F, Lanzavecchia, A |
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Format: | Journal article |
Language: | English |
Published: |
Nature Research
2017
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