ATTACHMENT OF VITAMIN-E DERIVATIVES TO OLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESIS
Compounds have been synthesized which allow the attachment of Vitamin E to the 5′-, and 3′-ends of oligonucleotides, and the attachment of a Vitamin E moiety on an octamethylene spacer to the 5′-end, all during solid-phase synthesis. The effects on cellular uptake, distribution, and antiviral activi...
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| Format: | Journal article |
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1992
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