ATTACHMENT OF VITAMIN-E DERIVATIVES TO OLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESIS
Compounds have been synthesized which allow the attachment of Vitamin E to the 5′-, and 3′-ends of oligonucleotides, and the attachment of a Vitamin E moiety on an octamethylene spacer to the 5′-end, all during solid-phase synthesis. The effects on cellular uptake, distribution, and antiviral activi...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Published: |
1992
|
| _version_ | 1797079788605669376 |
|---|---|
| author | Will, D Brown, T |
| author_facet | Will, D Brown, T |
| author_sort | Will, D |
| collection | OXFORD |
| description | Compounds have been synthesized which allow the attachment of Vitamin E to the 5′-, and 3′-ends of oligonucleotides, and the attachment of a Vitamin E moiety on an octamethylene spacer to the 5′-end, all during solid-phase synthesis. The effects on cellular uptake, distribution, and antiviral activity of the attachment of the extremely lipophilic Vitamin E moiety to phosphorothioate 'antisense' oligonucleotides are now being investigated. © 1992. |
| first_indexed | 2024-03-07T00:50:48Z |
| format | Journal article |
| id | oxford-uuid:8655fdf5-bf89-43c4-ab37-d0703eb43b4d |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:50:48Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:8655fdf5-bf89-43c4-ab37-d0703eb43b4d2022-03-26T22:03:14ZATTACHMENT OF VITAMIN-E DERIVATIVES TO OLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESISJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8655fdf5-bf89-43c4-ab37-d0703eb43b4dSymplectic Elements at Oxford1992Will, DBrown, TCompounds have been synthesized which allow the attachment of Vitamin E to the 5′-, and 3′-ends of oligonucleotides, and the attachment of a Vitamin E moiety on an octamethylene spacer to the 5′-end, all during solid-phase synthesis. The effects on cellular uptake, distribution, and antiviral activity of the attachment of the extremely lipophilic Vitamin E moiety to phosphorothioate 'antisense' oligonucleotides are now being investigated. © 1992. |
| spellingShingle | Will, D Brown, T ATTACHMENT OF VITAMIN-E DERIVATIVES TO OLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESIS |
| title | ATTACHMENT OF VITAMIN-E DERIVATIVES TO OLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESIS |
| title_full | ATTACHMENT OF VITAMIN-E DERIVATIVES TO OLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESIS |
| title_fullStr | ATTACHMENT OF VITAMIN-E DERIVATIVES TO OLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESIS |
| title_full_unstemmed | ATTACHMENT OF VITAMIN-E DERIVATIVES TO OLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESIS |
| title_short | ATTACHMENT OF VITAMIN-E DERIVATIVES TO OLIGONUCLEOTIDES DURING SOLID-PHASE SYNTHESIS |
| title_sort | attachment of vitamin e derivatives to oligonucleotides during solid phase synthesis |
| work_keys_str_mv | AT willd attachmentofvitaminederivativestooligonucleotidesduringsolidphasesynthesis AT brownt attachmentofvitaminederivativestooligonucleotidesduringsolidphasesynthesis |