Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle.

Obesity is increasingly prevalent, strongly associated with nonalcoholic liver disease, and a risk factor for numerous cancers. Here, we describe the liver-related consequences of long-term diet-induced obesity. Mice were exposed to an extended obesity model comprising a diet high in trans-fats and...

Full description

Bibliographic Details
Main Authors: Dowman, J, Hopkins, L, Reynolds, G, Nikolaou, N, Armstrong, M, Shaw, J, Houlihan, D, Lalor, P, Tomlinson, J, Hübscher, S, Newsome, P
Format: Journal article
Language:English
Published: Elsevier 2014