Oxetane cis- and trans beta-amino-acid scaffolds from D-xylose by efficient S(N)2 reactions in oxetane rings: methyl and hydroxymethyl analogues of the antibiotic oxetin, an oxetane beta-amino-acid

Highly regioselective reactions of a benzylidene-protected oxetane with (i) triethylsilane-trifluoroacetic acid and (ii) Hanessian-Hullar bromination provide efficient access to 3-hydroxyoxetane carboxylates in which only the C-3 OH is unprotected. Subsequent nucleophilic displacements of the corres...

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Bibliografische gegevens
Hoofdauteurs: Jenkinson, S, Harris, T, Fleet, G
Formaat: Journal article
Taal:English
Gepubliceerd in: 2004