A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.

The identification of mutated metabolic enzymes in hereditary cancer syndromes has established a direct link between metabolic dysregulation and cancer. Mutations in the Krebs cycle enzyme, fumarate hydratase (FH), predispose affected individuals to leiomyomas, renal cysts, and cancers, though the r...

Full description

Bibliographic Details
Main Authors:	Adam, J, Yang, M, Bauerschmidt, C, Kitagawa, M, O'Flaherty, L, Maheswaran, P, Özkan, G, Sahgal, N, Baban, D, Kato, K, Saito, K, Iino, K, Igarashi, K, Stratford, M, Pugh, C, Tennant, D, Ludwig, C, Davies, B, Ratcliffe, P, El-Bahrawy, M, Ashrafian, H, Soga, T, Pollard, P
Format:	Journal article
Language:	English
Published:	2013

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.

Similar Items