Prion-like α-synuclein pathology in the brain of infants with Krabbe disease

Krabbe disease is an infantile neurodegenerative disorder resulting from pathogenic variants in the GALC gene that causes accumulation of the toxic sphingolipid psychosine. GALC variants are also associated with Lewy body diseases, an umbrella term for age-associated neurodegenerative diseases in wh...

Full description

Bibliographic Details
Main Authors: Hatton, C, Ghanem, SS, Koss, DJ, Abdi, IY, Gibbons, E, Guerreiro, R, Bras, J, Walker, L, Gelpi, E, Heywood, W, Outeiro, TF, Attems, J, McFarland, R, Forsyth, R, El-Agnaf, OM, Erskine, D
Other Authors: International DLB Genetics Consortium
Format: Journal article
Language:English
Published: Oxford University Press 2022