Hydroxylation of eleuthoside synthetic intermediates by P450BM3 (CYP102A1)
A seven‐step synthesis of the first tricyclic intermediate in Danishefsky's total synthesis of eleutherobin is reported with Wittig homologation and sequential additions of metallated furan derivatives to aldehydes as key steps. Aiming to prepare hydroxylated eleutherobin analogues for cytotoxi...
| Main Authors: | , , |
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| Format: | Journal article |
| Published: |
Wiley
2018
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