A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.

A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.

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BACKGROUND: CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of th...

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Bibliographic Details
Main Authors: Buranapraditkun, S, Hempel, U, Pitakpolrat, P, Allgaier, R, Thantivorasit, P, Lorenzen, S, Sirivichayakul, S, Hildebrand, W, Altfeld, M, Brander, C, Walker, B, Phanuphak, P, Hansasuta, P, Rowland-Jones, S, Allen, T, Ruxrungtham, K
Format: Journal article
Language:English
Published: Public Library of Science 2011

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