CRISPRi: a way to integrate iPSC-derived neuronal models

The genetic landscape of neurodegenerative diseases encompasses genes affecting multiple cellular pathways which exert effects in an array of neuronal and glial cell-types. Deconvolution of the roles of genes implicated in disease and the effects of disease-associated variants remains a vital step i...

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Bibliographic Details
Main Authors: Franks, SNJ, Heon-Roberts, R, Ryan, B
Format: Journal article
Language:English
Published: Portland Press 2024