Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses.

The strength of T-cell receptor (TCR) stimulation and subsequent T-cell response depend on a combination of peptide-major histocompatibility complex (pMHC) density and potency. By comparing two different pMHC at doses yielding similar proliferation in vivo, we have highlighted unexpected differences...

Повний опис

Бібліографічні деталі
Автори: Gottschalk, R, Hathorn, M, Beuneu, H, Corse, E, Dustin, M, Altan-Bonnet, G, Allison, J
Формат: Journal article
Мова:English
Опубліковано: 2012