Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation
Gene therapy for systemic diseases requires intravenous administration, but existing vectors are not suitable for systemic delivery, often showing rapid elimination from the bloodstream that restricts potential transfection sites to “first-pass” organs. To develop long-circulating vectors, here we h...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Published: |
Cell Press
2002
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