Thymic involution and rising disease incidence with age.

Thymic involution and rising disease incidence with age.

For many cancer types, incidence rises rapidly with age as an apparent power law, supporting the idea that cancer is caused by a gradual accumulation of genetic mutations. Similarly, the incidence of many infectious diseases strongly increases with age. Here, combining data from immunology and epide...

Полное описание

Библиографические подробности
Главные авторы:	Palmer, S, Albergante, L, Blackburn, CC, Newman, TJ
Формат:	Journal article
Язык:	English
Опубликовано:	National Academy of Sciences 2018

Схожие документы

Reply to Jiménez-Alonso et al., Schooling and Zhao, and Mortazavi: Further discussion on the immunological model of carcinogenesis
по: Palmer, S, и др.
Опубликовано: (2018)

Human Thymic Involution and Aging in Humanized Mice
по: Qing-Yue Tong, и др.
Опубликовано: (2020-07-01)

Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
по: Rachel Thomas, и др.
Опубликовано: (2020-01-01)

MicroRNA Functions in Thymic Biology: Thymic Development and Involution
по: Minwen Xu, и др.
Опубликовано: (2018-09-01)

Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution.
по: Kathy E O'Neill, и др.
Опубликовано: (2016-01-01)

Peripubertal orchidectomy transitorily affects age-associated thymic involution in rats
по: V. Pesic, и др.
Опубликовано: (2007-11-01)

MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors
по: Minwen Xu, и др.
Опубликовано: (2017-01-01)

Overexpression of lymphotoxin in T cells induces fulminant thymic involution.
по: Heikenwalder, M, и др.
Опубликовано: (2008)

Tyrosine phosphorylation related to thymic involution induced by diet restriction in comparison with aging
по: Izumi Takase
Опубликовано: (2020-12-01)

TGF- 2signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution
по: Hauri-Hohl, M, и др.
Опубликовано: (2008)

TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.
по: Hauri-Hohl, M, и др.
Опубликовано: (2008)

Thymus ad astra, or spaceflight-induced thymic involution
по: Wataru Muramatsu, и др.
Опубликовано: (2025-01-01)

Multiple thymi and no thymic involution in naked mole rats?
по: Graham Pawelec
Опубликовано: (2021-11-01)

Global Transcriptional Profiling Reveals Distinct Functions of Thymic Stromal Subsets and Age-Related Changes during Thymic Involution
по: Sanghee Ki, и др.
Опубликовано: (2014-10-01)

Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells
по: Shiyun Xiao, и др.
Опубликовано: (2023-10-01)

Dendritic cell-intrinsic Ezh2 expression maintains thymic homeostasis and prevents premature thymic involution
по: Sint Thida Bo
Опубликовано: (2023)

Transcriptional profile of human thymus reveals IGFBP5 is correlated with age-related thymic involution
по: Xiaojing Yang, и др.
Опубликовано: (2024-01-01)

Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the “obesity paradox”
по: Logan V. Vick, и др.
Опубликовано: (2023-01-01)

Alterations of Thymic Epithelial Cells in Lipopolysaccharide-induced Neonatal Thymus Involution
по: Yong-Jie Zhou, и др.
Опубликовано: (2016-01-01)

COVID-19 hospitalization rates rise exponentially with age, inversely proportional to thymic T-cell production
по: Palmer, S, и др.
Опубликовано: (2021)

Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients
по: Craig P. Collins, и др.
Опубликовано: (2024-09-01)

IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection
по: Lei Xu, и др.
Опубликовано: (2022-11-01)

The effect of age on thymic function
по: Donald B. Palmer
Опубликовано: (2013-10-01)

A Proposed Link Between Acute Thymic Involution and Late Adverse Effects of Chemotherapy
по: Maria K. Lagou, и др.
Опубликовано: (2022-07-01)

Are zinc-bound metallothionein isoforms (I+II and III) involved in impaired thymulin production and thymic involution during ageing?
по: Cipriano Catia, и др.
Опубликовано: (2004-11-01)

Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution
по: María Jesús García-León, и др.
Опубликовано: (2022-05-01)

Thymic Involution and Altered Naive CD4 T Cell Homeostasis in Neuromyelitis Optica Spectrum Disorder
по: Haoxiao Chang, и др.
Опубликовано: (2021-07-01)

Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy
по: Soo Hyun Ahn, и др.
Опубликовано: (2022-04-01)

Expression of the HPV16E7 Oncoprotein by Thymic Epithelium is Accompanied by Disrupted T Cell Maturation and a Failure of the Thymus to Involute with Age
по: I. H. Frazer, и др.
Опубликовано: (2003-01-01)

In vitro fertilization pregnancy may cause fetal thymic volume involution: A case-control study
по: Nurgul Selin Kaya, и др.
Опубликовано: (2023-11-01)

Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis.
по: Kana Unuma, и др.
Опубликовано: (2022-01-01)

Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis
по: Kana Unuma, и др.
Опубликовано: (2022-01-01)

Corrigendum: Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy
по: Soo Hyun Ahn, и др.
Опубликовано: (2022-06-01)

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.
по: Papadopoulou, A, и др.
Опубликовано: (2012)

Thymic epithelial organoids mediate T-cell development
по: Hübscher, T, и др.
Опубликовано: (2024)

Trends in the incidence of thymoma, thymic carcinoma, and thymic neuroendocrine tumor in the United States.
по: Chun-Hsiang Hsu, и др.
Опубликовано: (2019-01-01)

Postnatal Involution and Counter-Involution of the Thymus
по: Jennifer E. Cowan, и др.
Опубликовано: (2020-05-01)

Circulating mature dendritic cells homing to the thymus promote thymic epithelial cells involution via the Jagged1/Notch3 axis
по: Haojie Wu, и др.
Опубликовано: (2021-08-01)

Incidence, mortality, and survival analyses of patients with thymic lymphoma
по: Li Wang, и др.
Опубликовано: (2022-09-01)

Transcriptome analysis reveals a potential regulatory mechanism of the lnc-5423.6/IGFBP5 axis in the early stages of mouse thymic involution
по: Li Bingxin, и др.
Опубликовано: (2023-04-01)