Tied up in loops: positive and negative autoregulation of p53.
The tumor suppressor p53 is a master sensor of stress that controls many biological functions, including implantation, cell-fate decisions, metabolism, and aging. In response to a defined stress signal such as gamma radiation, the response of p53 is heterogeneous in vivo. Like a complex barcode, the...
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| Format: | Journal article |
| Language: | English |
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2010
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