Characterising CD8+ T cell transcriptomic and clonal consequences of immune checkpoint blockade for the treatment of cancer
<p><b>Background:</b> Immune checkpoint blockade (ICB) is arguably the greatest advance in medical oncology this century. Nonetheless, responses are highly variable. Mechanistic insights into this heterogeneity promises to improve patient stratification and identification of thera...
Main Author: | Watson, RA |
---|---|
Other Authors: | Fairfax, B |
Format: | Thesis |
Language: | English |
Published: |
2023
|
Subjects: |
Similar Items
-
Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity
by: Watson, R, et al.
Published: (2021) -
Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade
by: Sharmila Nair, et al.
Published: (2021-01-01) -
Dissecting peripheral CD8+ T cell responses and immune interactions during immune checkpoint blockade for metastatic melanoma
by: Tong, O
Published: (2023) -
Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma
by: Cristina Valero, et al.
Published: (2023-10-01) -
Mathematical modelling and transcriptional characterisation of intratumoral regulatory T cell sub-populations
by: Muzhingi, I
Published: (2023)