Peroxynitrite activated drug conjugate systems based on a coumarin scaffold toward the application of theranostics
Two novel drug-conjugates based on a “coumarin linker” have been designed for the synergic release of a therapeutic agent and fluorescent probe for the potential application of theranostics. The drug conjugates; CC-RNS and CI-RNS were designed to be activated by reactive oxygen species or reactive n...
| Päätekijät: | , , , , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
Frontiers Media
2019
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| _version_ | 1826283253620801536 |
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| author | Odyniec, M Han, H Gardiner, J Sedgwick, A He, X Bull, S James, T |
| author_facet | Odyniec, M Han, H Gardiner, J Sedgwick, A He, X Bull, S James, T |
| author_sort | Odyniec, M |
| collection | OXFORD |
| description | Two novel drug-conjugates based on a “coumarin linker” have been designed for the synergic release of a therapeutic agent and fluorescent probe for the potential application of theranostics. The drug conjugates; CC-RNS and CI-RNS were designed to be activated by reactive oxygen species or reactive nitrogen species (ROS/RNS). The fluorescence OFF-ON response was triggered by the peroxynitrite-mediated transformation of a boronic acid pinacol ester to a phenol moiety with simultaneous release of the therapeutic agents (Confirmed by HRMS). The limit of detection for peroxynitrite using CC-RNS and CI-RNS was 0.29 and 37.2 μM, respectively. Both CC-RNS and CI-RNS demonstrated the ability to visualize peroxynitrite production thus demonstrating the effectiveness of these probes for use as tools to monitor peroxynitrite-mediated drug release in cancer cell lines. |
| first_indexed | 2024-03-07T00:56:08Z |
| format | Journal article |
| id | oxford-uuid:882611d2-c7fb-4abc-928e-ee6fbfaccff4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:56:08Z |
| publishDate | 2019 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:882611d2-c7fb-4abc-928e-ee6fbfaccff42022-03-26T22:15:07ZPeroxynitrite activated drug conjugate systems based on a coumarin scaffold toward the application of theranosticsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:882611d2-c7fb-4abc-928e-ee6fbfaccff4EnglishSymplectic Elements at OxfordFrontiers Media2019Odyniec, MHan, HGardiner, JSedgwick, AHe, XBull, SJames, TTwo novel drug-conjugates based on a “coumarin linker” have been designed for the synergic release of a therapeutic agent and fluorescent probe for the potential application of theranostics. The drug conjugates; CC-RNS and CI-RNS were designed to be activated by reactive oxygen species or reactive nitrogen species (ROS/RNS). The fluorescence OFF-ON response was triggered by the peroxynitrite-mediated transformation of a boronic acid pinacol ester to a phenol moiety with simultaneous release of the therapeutic agents (Confirmed by HRMS). The limit of detection for peroxynitrite using CC-RNS and CI-RNS was 0.29 and 37.2 μM, respectively. Both CC-RNS and CI-RNS demonstrated the ability to visualize peroxynitrite production thus demonstrating the effectiveness of these probes for use as tools to monitor peroxynitrite-mediated drug release in cancer cell lines. |
| spellingShingle | Odyniec, M Han, H Gardiner, J Sedgwick, A He, X Bull, S James, T Peroxynitrite activated drug conjugate systems based on a coumarin scaffold toward the application of theranostics |
| title | Peroxynitrite activated drug conjugate systems based on a coumarin scaffold toward the application of theranostics |
| title_full | Peroxynitrite activated drug conjugate systems based on a coumarin scaffold toward the application of theranostics |
| title_fullStr | Peroxynitrite activated drug conjugate systems based on a coumarin scaffold toward the application of theranostics |
| title_full_unstemmed | Peroxynitrite activated drug conjugate systems based on a coumarin scaffold toward the application of theranostics |
| title_short | Peroxynitrite activated drug conjugate systems based on a coumarin scaffold toward the application of theranostics |
| title_sort | peroxynitrite activated drug conjugate systems based on a coumarin scaffold toward the application of theranostics |
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