The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression
Tumor neo-angiogenesis is regulated, in part, by the hypoxia-inducible gene <em>HIF1</em>.. Evidence suggests <em>HIF1</em> associates with polymerized microtubules and traffics to the nucleus. This study investigated the role of HIF1 in mediating the antitumor activity of tw...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
International Institute of Anticancer Research
2015
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