Tyrosine 1-phosphorylated RNA polymerase II transcribes PROMPTs to facilitate proximal promoter pausing and induce global transcriptional repression in response to DNA damage
<p>DNA damage triggers a complex transcriptional response that involves both activation and repression of gene expression. In this study, we investigated global changes in transcription in response to ionizing irradiation (IR), which induces double-strand breaks in DNA. We used mNET-seq to pro...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cold Spring Harbor Laboratory
2024
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