Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours.
The roles of the intrinsic mutation rate and genomic instability in tumorigenesis are currently controversial. In most colorectal tumours, it is generally supposed that the first mutations occur at the adenomatous polyposis coli (APC) locus; APC mutations are thought to provide cells with a selectiv...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
John Wiley and Sons Inc.
1998
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