Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available. Here we report cyclic peptide inhibitors of the KDM4A-C with selectivity over other KDMs / 2OG oxygenases, including clo...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Nature Publishing Group
2017
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