Structural and mechanistic studies on prolyl hydroxylases
<p>Oxygen dependent prolyl-4-hydroxylation of the alpha-subunit of the hypoxia inducible transcription factor (HIF-alpha) plays an essential role in the hypoxic response. Hydroxylation of proline residues in the N- or C-terminal oxygen dependent degradation domains (NODD or CODD) increases the...
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Format: | Thesis |
Language: | English |
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2008
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