Hodgkin–Huxley revisited: reparametrization and identifiability analysis of the classic action potential model with approximate Bayesian methods

As cardiac cell models become increasingly complex, a correspondingly complex ‘genealogy’ of inherited parameter values has also emerged. The result has been the loss of a direct link between model parameters and experimental data, limiting both reproducibility and the ability to re-fit to new data....

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Bibliographic Details
Main Authors: Daly, A, Gavaghan, D, Holmes, C, Cooper, J
Format: Journal article
Language:English
Published: Royal Society 2015